Ppar alpha activation assay

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Note that each number in parentheses [1, 2, 3, etc. PPAR alpha is a very important protein for metabolizing fat and for weight loss.

This post is about its related kin PPAR alpha, which has somewhat different effects. PPAR-alpha is a protein transcription factor that increases fat breakdown in the liver and elsewhere.

A good metabolism is important for energy production. PPAR-alpha is activated under conditions of calorie restriction and is necessary for the process of ketogenesis , a key adaptive response to prolonged fasting. PPAR-alpha is mainly found in the liver and brown fat, followed by the heart and kidney. Purchase these through your usual distributor. In the coming months Additional product types Supporting content Sign in to your account Purchase online.

Your name Your email. Send me a copy of this email. I agree to the terms and conditions. Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety By similarity. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Belongs to the nuclear hormone receptor family. NR1 subfamily.

Contains 1 nuclear receptor DNA-binding domain. In addition, fenofibrate strongly sensitized BI6FIO cells to the proapoptotic drug staurosporine, further supporting the possibility that fenofibrate-induced down-regulation of Akt function contributes to fenofibrate-mediated inhibition of metastatic potential in this experimental model. Conclusions: Our results show that the PPAR-dependent antimetastatic activity of fenofibrate involves down-regulation of Akt phosphorylation and suggest that supplementation with this drug may improve the effectiveness of melanoma chemotherapy.

Abstract Purpose: Peroxisome proliferator-activated receptors PPAR regulate lipid and glucose metabolism but their anticancer properties have been recently studied as well.